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Background: S1P1/EDG-1. S1P1, also known as EDG-1, is a member of the endothelial differentiation gene family. It is a high affinity G protein-coupled receptor Intracellularly S1P regulates proliferation and survival; extracellularly S1P is a ligand for EDG1 (also known as S1P1). Activation of sphingosine kinase (SPHK), Type: Primary Antigen: S1PR1 (sphingosine-1-phosphate receptor 1) Clonality: polyclonal. Clone: Conjugation: unconjugated.

S1pr1 gene

28,33 S1PR1 is also highly expressed in endothelial cells and pericytes, and the expression of S1PR1 within these cells is important for tumor angiogenesis and metastasis. 34,35 On the other hand, blocking S1PR1 can retain lymphoma cells in lymphoid organs because of an egress function NCBI Description of S1PR1: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Description: Homo sapiens sphingosine-1-phosphate receptor 1 (S1PR1), transcript variant 1, mRNA. (from RefSeq NM_001400) RefSeq Summary (NM_001400): The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be Edg1 eGFP/eGFP knock-in mice have an EGFP gene inserted downstream of the coding region of the sphingosine-1-phosphate receptor 1 (S1pr1, also known as S1P 1) gene.

The S1PR1 gene encodes a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). There are 5 known S1P receptors with distinct but overlapping regulatory functions in normal physiology and disease processes, particularly involving the immune, central nervous, and cardiovascular systems. S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G (i) subclass We used an inducible mouse model with a temporally disrupted sphingosine-1-phosphate receptor-1 (S1PR1) gene specifically in endogenous effector T cells.

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Anti-S1PR1 Rabbit polyclonal antibody unconjugated VWR

S1P sensitizes ICAPS through G-protein coupled S1P1 receptor activation of Galphai-PI3K-PKC-p38 signaling pathway in sensory neurons Functional Associations. S1PR1 has 4,557 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 77 datasets. PrimePCR™ PreAmp for SYBR® Green Assay: S1PR1, Human Reaction: 400 reactions Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis. The S1PR1 gene encodes a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P).

155 by in vitro and in vivo studies; its expression was decreased in SLE EDG1 is a member of the endothelial differentiation gene family. It is a high affinity G protein-coupled receptor for the bioactive lipid, Sphingosine-1- phosphate. 3 Mar 2020 S1pr1 encodes a G-protein-coupled receptor (S1P1) that binds the bioactive signaling molecule sphingosine-1-phosphate (S1P) and is involved tioning downstream of elevated S1P, which contributes to increased S1P receptor 1 (S1pr1) gene expression in the macrophages of several tissues in SCD mice CD363 (S1PR1) Monoclonal Antibody (SW4GYPP), eFluor 660, eBioscience™ Invitrogen catalog: EDG1 (Endothelial Cell Differentiation Gene 1) (APC) 25 Mar 2014 We created an S1P1 (S1pr1) gene-targeting vector that carried a bicistronic unit consisting of the S1P1-tTA fusion followed by a mouse β-arrestin- 7 Mar 2019 Although sphingosine-1-phosphate receptor 1 (S1P1) has been When S1PR1 gene was ablated in the germ line of mice it resulted in a lethal. 10 Sep 2012 We induced S1pr1 gene deletion specifically in endothelial cells using VE- cadherin (Cdh5) promoter-driven Cre recombinase expression by 18 Mar 2020 S1pr1, the gene that encodes S1P1, is highly expressed in endothelial cells, lymphocytes, neuronal cells, and cardiomyocytes [3-6]. Global and S1PR1 (Myc-DDK-tagged)-Human sphingosine-1-phosphate receptor 1 (S1PR1) Expression varies depending on the nature of the gene. Product 19 Nov 2018 Sphingosine-1-phosphate receptor 1 (S1PR1), is encoded by the S1PR1 gene, also known as endothelial differentiation gene 1 (EDG1).
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Conclusion Our study demonstrated that high expression of S1PR1 contributed to the proliferation and survival of ESCC cells via activating STAT3 signaling pathway. NCBI Description of S1PR1: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belon Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1P1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene.

doi: 10.1038/nsmb.3014. Epub 2015 Apr 20.
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tr A0JLZ7 A0JLZ7_XENTR Uncharacterized protein OS

It is essential for vascular development and integrity, and modulates both lymphocyte development and The following S1pr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S1pr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. The S1PR1 gene was mapped to river buffalo chromosome 6 using a radiation hybrid panel (Stafuzza et al., 2007). In cattle, quantitative trait locus analysis revealed that the gene is located on chromosome 3 within a region for marbling of meat and is considered a candidate Construct Details: Full length human S1PR1 gene is subcloned into the Lentiviral expression vector pLTC with an upstream CMV promoter and with or without an antibiotic selection marker, which can be used for both transient and stable expression in mammalian cells. 2018-03-01 The gene S1PR1 may have Genomic and Proteomic products available from Sigma-Aldrich.